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Template:On this day - April 6
From Hispanopedia

- 1503 – On the Caribbean coast of Veraguas (present-day Panama), the natives attack Santa María de Belén (the first settlement founded by Christopher Columbus on the American mainland).
- 1510 – In Spain, a Mozarab from Málaga introduces the technique of intaglio engraving.
- 1606 – In Spain, the court of Philip III of Spain moves from Valladolid to Madrid.
- 1713 – In Madrid (Spain), the Spanish Academy of the Language meets for the first time, in the house of its promoter, the Marquis of Villena.
- 1717 – Birth of Luis de Unzaga y Amézaga, Spanish soldier and administrator in America, governor of Louisiana, Venezuela and Cuba, as well as of Galicia and the former Kingdom of Granada in Spain. As a man of the Enlightenment, he created the world's first bilingual public education system (d. 1793).
- 1732 – Birth of José Celestino Mutis, Spanish mathematician and botanist (d. 1808).
- 1897 – Birth of Jesús T. Piñero, Puerto Rican engineer, Governor of Puerto Rico between 1946 and 1949 (d. 1952).
- 1911 – Death of Evaristo Madero Elizondo, Mexican businessman, soldier and politician (b. 1828).
- 1835 – Death of José Agustín Caballero, Cuban priest, theologian and philosopher.
- 1852 – In Palermo (5 km north of Buenos Aires), Buenos Aires, Entre Ríos, Corrientes and Santa Fe sign the Palermo Protocol.
- 1914 – Signing of the Thomson–Urrutia Treaty in Bogotá between the United States and Colombia, to try to resolve the conflict between Americans and Colombians caused by the support the United States gave to the separation of Panama from Colombia.
- 1963 – Birth of Rafael Correa, Ecuadorian politician, professor and economist, President of Ecuador between 2007 and 2017.
- 1964 – In La Plata (capital of the province of Buenos Aires), the Catholic University of La Plata is created.
- 1970 – In Guatemala, the German ambassador Karl von Spreti is murdered.
- 1983 – In Managua (Nicaragua), Comandante Ana María (53), Salvadoran guerrilla and founder of the FMLN (Farabundo Martí National Liberation Front), is murdered.
- 2010 – Death of Guillermo Luca de Tena, Spanish journalist, honorary president of the Vocento Group (b. 1927).
- 2014 – In Costa Rica, Luis Guillermo Solís is elected president.