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Template:On this day - April 21
From Hispanopedia

- 25 BC – Founding of Augusta Emerita, an ancient Roman city, today Mérida (Spain).
- 900 – The Laguna Copperplate Inscription, the oldest written record of the Philippines, is dated.
- 1211 – The Archdiocese of Santiago de Compostela consecrates the Cathedral of Santiago de Compostela in the presence of King Alfonso IX of León.
- 1483 – During the Battle of Lucena (in the present-day province of Córdoba), Boabdil, last Sultan of the Nasrid Kingdom of Granada, is taken prisoner.
- 1503 – In the course of the War of Naples (1501-1504), the troops of the Crown of Castile and Aragon defeat the French at the Battle of Seminara.
- 1569 – Death of Hernán Ruiz Jiménez, Spanish architect (b. 1514).
- 1582 – Death of Francisco de Toledo, Spanish aristocrat and soldier (b. 1515).
- 1594 – The village of San Salvador (today the capital of El Salvador, which at that time had only a few hundred inhabitants) suffers the third of its many major earthquakes, which destroys it completely.
- 1661 – Birth of Jiří Josef Camel, Jesuit botanist and missionary in the Marianas and the Philippines (d. 1706).
- 1691 – In the New Kingdom of Granada (present-day Colombia), the city of Cartago is moved to its present location because of the continual attacks of the Pijaos.
- 1744 – In New Spain (present-day state of Querétaro in Mexico), Colonel José de Escandón y Helguera founds the city of Jalpan de Serra.
- 1824 – Birth of Anselmo Clavé, Spanish poet, politician, composer and music director (d. 1874).
- 1836 – During the Texas Revolution, at the Battle of San Jacinto, the forces of the Republic of Texas under Sam Houston surprise and defeat the troops of the Mexican general Antonio López de Santa Anna, who were taking their siesta.
- 1866 – Isabella II of Spain lays the first stone of the National Library in Madrid.
- 1898 – The United States Congress declares war on Spain.
- 1914 – At the Port of Veracruz (Mexico), the United States begins the second U.S. intervention in Mexico.
- 2010 – Death of Juan Antonio Samaranch, Spanish sports leader, businessman and politician, president of the International Olympic Committee between 1980 and 2001 (b. 1920).
- 2019 – In Cauca (Colombia), a landslide caused by heavy rains leaves 32 dead and several injured.
- 2025 – Death of Pope Francis, 266th Pope of the Catholic Church (b. 1936).